Fluorescent Probes Based on AIEgen‐Mediated Polyelectrolyte Assemblies for Manipulating Intramolecular Motion and Magnetic Relaxivity. (10th February 2023)

• Record Type: Journal Article
• Authors: Yao, Yongkang; Ding, Peng; Yan, Chenxu; Tao, Yining; Peng, Bo; Liu, Weimin; Wang, Junyou; Cohen Stuart, Martien A.; Guo, Zhiqian
• Is Part Of: Angewandte Chemie. Volume 135:Number 13(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-10
• Subjects: Aggregation-Induced-Emission -- Excited-State Intramolecular Motion -- Fluorescent Probe -- Magnetic Relaxivity -- Polyelectrolyte; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202218983
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Uniting photothermal therapy (PTT) with magnetic resonance imaging (MRI) holds great potential in nanotheranostics. However, the extensively utilized hydrophobicity‐driven assembling strategy not only restricts the intramolecular motion‐induced PTT, but also blocks the interactions between MR agents and water. Herein, we report an aggregation‐induced emission luminogen (AIEgen)‐mediated polyelectrolyte nanoassemblies (APN) strategy, which bestows a unique "soft" inner microenvironment with good water permeability. Femtosecond transient spectra verify that APN well activates intramolecular motion from the twisted intramolecular charge transfer process. This de novo APN strategy uniting synergistically three factors (rotational motion, local motion, and hydration number) brings out high MR relaxivity. For the first time, APN strategy has successfully modulated both intramolecular motion and magnetic relaxivity, achieving fluorescence lifetime imaging of tumor spheroids and spatio‐temporal MRI‐guided high‐efficient PTT. Abstract : Here we break the bottleneck of uncontrollable inner microenvironment from the hydrophobicity‐driven assembling strategy, and present a fluorescent probe based AIEgen‐mediated polyelectrolyte nanoassemblies (APN) strategy. By modulating a "soft" and water‐rich inner microenvironment in nanotheranostics, APN strategy has for the first time synergistically manipulated both intramolecular motion and magnetic relaxivity.