Prevalence and trend of allergen sensitization in patients with cheilitis referred for patch testing, North American Contact Dermatitis Group data, 2001–2018. (20th December 2022)

• Record Type: Journal Article
• Authors: Silverberg, Jonathan I.; Chaubal, Manotri; Warshaw, Erin M.; Maibach, Howard I.; Belsito, Donald V.; DeKoven, Joel G.; Zug, Kathryn A.; Taylor, James S.; Sasseville, Denis; DeLeo, Vincent A.; Pratt, Melanie D.; Reeder, Margo J.; Atwater, Amber R.; Fowler, Joseph F.; Houle, Marie‐Claude
• Is Part Of: Contact dermatitis. Volume 88:Number 4(2023)
• Page Start: 300
• Page End: 314
• Publication Date: 2022-12-20
• Subjects: allergic contact -- cheilitis -- dermatitis -- dermatitis -- epidemiology -- health -- itch -- lip dermatitis -- patch test -- pruritus -- rash; Contact dermatitis -- Periodicals; 616.51
• DOI: 10.1111/cod.14265
• Languages: English
• ISSNs: 0105-1873

Abstract

Abstract: Background: An updated understanding of allergic contact cheilitis is needed. Objectives: To characterize clinical characteristics and allergen relevance in patients with cheilitis referred for patch testing. Methods: Retrospective analysis of 43 772 patients patch tested with the North American Contact Dermatitis Group (NACDG) screening series from 2001 to 2018. Results: Overall, 2094 patients (4.8%) had lips as one of three sites of dermatitis, 1583 (3.6%) had lips as the primary site and 1167 (2.7%) had lips as the sole site of dermatitis. Prevalences of cheilitis at any, primary, and sole sites significantly increased throughout the study cycle from 2001–2002 (2.7%, 2.2% and 1.7%) to 2017–2018 (7.8%, 5.2% and 3.7%). Approximately 60% of patients with any, a primary, or a sole site of cheilitis had one or more positive allergic patch‐test reactions compared to 65% of those without cheilitis. Conclusion: Patients with cheilitis who were referred for patch testing had high rates of positive and relevant allergens. More than one in four patients with any, primary, or sole cheilitis had a positive reaction to non‐NACDG screening allergens (28.0%, 26.8%, 31.1% vs. 21.6%) compared to patients without cheilitis, emphasizing the need for expanded patch test series in cheilitis. Abstract : This retrospective analysis of 43 772 patients patch tested with the North American Contact Dermatitis Group screening series from 2001 to 2018 found that cheilitis was associated with high proportions of positive and relevant patch‐test reactions, including nickel sulphate hexahydrate, fragrances and more recently lanolin and propolis.