Short‐term neurochemical effects of transcutaneous trigeminal nerve stimulation using 7T magnetic resonance spectroscopy. Issue 2 (10th December 2022)

• Record Type: Journal Article
• Authors: Ritland, Bradley M.; Neumeier, William H.; Jiang, Sam H.; Smith, Carl D.; Heaton, Kristin J.; Hildebrandt, Audrey M.; Jabbar, Muhammad A.; Liao, Hui Jun; Coello, Eduardo; Zhao, Wufan; Bay, Camden P.; Lin, Alexander P.
• Is Part Of: Journal of neuroimaging. Volume 33:Issue 2(2023)
• Page Start: 279
• Page End: 288
• Publication Date: 2022-12-10
• Subjects: magnetic resonance spectroscopy -- neurochemistry -- transcutaneous nerve stimulation -- trigeminal nerve -- ultrahigh‐field MR; Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.13074
• Languages: English
• ISSNs: 1051-2284

Abstract

Abstract: Background and Purpose: The purpose was to explore the effects of transcutaneous trigeminal nerve stimulation (TNS) on neurochemical concentrations (brainstem, anterior cingulate cortex [ACC], dorsolateral prefrontal cortex [DLPFC], ventromedial prefrontal cortex [VMPFC], and the posterior cingulate cortex [PCC]) using ultrahigh‐field magnetic resonance spectroscopy. Methods: This double‐blinded study tested 32 healthy males (age: 25.4 ± 7.3 years) on two separate occasions where participants received either a 20‐minute TNS or sham session. Participants were scanned at baseline and twice post‐TNS/sham administration. Results: There were no group differences in concentration changes of glutamate, gamma‐aminobutyric acid, glutamine, myoinositol (mI), total N ‐acetylaspartate, total creatine (tCr), and total choline between the baseline scan and the first post‐TNS/sham scan and between the first and second post‐TNS/sham scan in the brainstem, ACC, DLPFC, VMPFC, and PCC. Between the baseline scan and the second post‐TNS/sham scan, changes in tCr (mean difference = 0.280 mM [0.075 to 0.485], p = .026) and mI (mean difference = 0.662 mM [0.203 to 1.122], p = .026) in the DLPFC differed between groups. Post hoc analyses indicated that there was a decrease in tCr (mean change = –0.201 mM [–0.335 to –0.067], p = .003) and no change in mI (mean change = –0.327 mM [–0.737 to 0.083], p = .118) in the TNS group; conversely, there was no change in tCr (mean change = –0.100 mM [–0.074 to 0.274], p = .259) and an increase in mI (mean change = 0.347 mM [0.106 to 0.588], p = .005) in the sham group. Conclusion: These data demonstrate that a single session of unilateral TNS slightly decreased tCr concentrations in the DLPFC region.