Solvent‐Free Choline Derivative Synthesis as a Powerful Organic Synthesis Medium. Issue 10 (9th March 2023)

• Record Type: Journal Article
• Authors: Kamali, Ehsan; Mohammadkhani, Abolfazl; Pazoki, Farzane; Heydari, Akbar
• Is Part Of: ChemistrySelect. Volume 8:Issue 10(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-09
• Subjects: Benzyl amine -- Choline amide -- Choline azide -- 1, 2, 3-triazole -- Solvent-free synthesis; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202204642
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: This study synthesized choline amide as a solvent‐free reagent and ion liquid in one pot to directly create benzylamine without producing associated salts. The synthesis of benzyl azide was also carried out with choline azide solventless, and 1, 2, 3‐triazole was prepared in the method mentioned. The synthesis of 1, 2, 3‐triazoles followed the process of a formal benzyl azide cycloaddition. For this purpose, a deep eutectic solvent was used as a catalyst to complete the nitrostyrene process. Both reactions were conducted with a high isolated yield without harmful solvents or catalysts. Eco‐friendly and economically feasible, the method also met environmental standards. Abstract : Note: this article is under preprint condition. With this title: "One‐pot and environmentally beneficial synthesis of benzylamine and 1, 2, 3‐triazole derivatives with choline chloride/sodium salts ."