PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer. Issue 4 (9th January 2023)

• Record Type: Journal Article
• Authors: Lin, Yijian; Lin, Peihuang; Guo, Weifeng; Huang, Junling; Xu, Xiaoting; Zhuang, Xibin
• Is Part Of: Environmental toxicology. Volume 38:Issue 4(2023)
• Page Start: 941
• Page End: 949
• Publication Date: 2023-01-09
• Subjects: E2F1 -- lung cancer -- PLAGL2 -- stemness -- transcriptional factor; Water quality bioassay -- Periodicals; Water -- Pollution -- Toxicology -- Periodicals; Microbiological assay -- Periodicals; Toxicity testing -- Periodicals; Environmental toxicology -- Periodicals; Environmental Pollution -- Periodicals; Environmental Pollutants -- Periodicals; Environmental Monitoring -- Periodicals; Écotoxicologie -- Périodiques; Pollution -- Périodiques; 615.902
• DOI: 10.1002/tox.23739
• Languages: English
• ISSNs: 1520-4081

Abstract

Abstract: This study mainly focuses on revealing the role of PLAGL2 in lung cancer stemness. In vitro and in vivo experiments were performed to evaluate the effects of PLAGL2 on lung cancer cell stemness. Mechanistic analysis using luciferase reporter and ChIP assays were implemented to reveal the underlying mechanisms. The transcriptional factor E2F1 transcriptionally activated PLAGL2 expression via directly binding to PLAGL2 promoter in lung cancer cells. Moreover, PLAGL2 promoted the stemness of lung cancer cells dependent on E2F1‐mediated transcriptional activation. This study provides a potential target for lung cancer progression.