Prognostic value and clinicopathological status of PD‐L1 expression and CD8+ TILs in oral squamous cell cancer patients with or without traditional risk factors. Issue 4 (21st February 2023)

• Record Type: Journal Article
• Authors: Soopanit, Thanion; Laokulrath, Natthawadee; Chayopasakul, Veeruth; Pongsapich, Warut
• Is Part Of: Head & neck. Volume 45:Issue 4(2023)
• Page Start: 1017
• Page End: 1025
• Publication Date: 2023-02-21
• Subjects: CD8 tumor‐infiltrating lymphocytes -- non‐betel quid chewer -- non‐drinker -- non‐smoker -- oral squamous cell cancer -- PD‐L1 -- smoker and/or drinker and/or betel quid chewer; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.27330
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Non‐smokers, non‐drinkers, and non‐betel quid chewers (NSNDNBs) with oral squamous cell carcinoma (OSCC) have poor survival outcomes. Tumor microenvironment based on PD‐L1/CD8+ T cell infiltrated lymphocyte (TIL) proportion is proposed as a prognostic indicator. Methods: Immunohistochemistry staining was performed on OSCC samples from 64 patients. The PD‐L1/CD8+ TILs were scored and stratified into four groups. Disease‐free survival (DFS) was analyzed using a Cox regression model. Results: OSCC in NSNDNB patients was associated with female sex, T1‐2 classification, and PD‐L1 positivity. Low CD8+ TILs correlated with perineural invasion. High CD8+ TILs correlated with improved DFS. PD‐L1 positivity was not correlated with DFS. Type IV tumor microenvironment yielded the highest DFS (85%). Conclusion: NSNDNB status relates to PD‐L1 expression regardless of CD8+ TILs infiltration. Type IV tumor microenvironment was associated with the best DFS. High CD8+ TILs resulted in better survival, while PD‐L1 positivity alone was not correlated to DFS.