Front Cover: In Situ Generated DBU⋅HF Acts as a Fluorinating Agent in a Hexafluoroisobutylation Tandem Reaction: An Effective Route to 5, 5, 5, 5', 5', 5'‐Hexafluoroleucine (Eur. J. Org. Chem. 10/2023). Issue 10 (27th February 2023)

• Record Type: Journal Article
• Authors: Naulet, Guillaume; Delamare, Aline; Guichard, Gilles; Compain, Guillaume
• Is Part Of: European journal of organic chemistry. Volume 26:Issue 10(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-27
• Subjects: fluoroalkylation -- fluorination -- amino acids -- stereoselective synthesis -- synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202300164
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The Front Cover illustrates the ability of DBU – the yellow tightrope walker – to preserve the fluoride nucleophilicity promoting the fluorination of a pentafluoroisobutenyl group – the five‐flower bouquet carried by the young lady – in a cascade reaction. In contrast, the alkali metals – the blue acrobats – precipitate with fluoride ions precluding a subsequent hydrofluorination. Cover created by Ludion. More information can be found in the Research Article by G. Guichard, G. Compain et al .