Whole‐brain steady‐state CEST at 3 T using MR Multitasking. Issue 5 (29th November 2021)

• Record Type: Journal Article
• Authors: Han, Pei; Cheema, Karandeep; Lee, Hsu‐Lei; Zhou, Zhengwei; Cao, Tianle; Ma, Sen; Wang, Nan; Han, Hui; Christodoulou, Anthony G.; Li, Debiao
• Is Part Of: Magnetic resonance in medicine. Volume 87:Issue 5(2022)
• Page Start: 2363
• Page End: 2371
• Publication Date: 2021-11-29
• Subjects: APT -- chemical exchange saturation transfer -- MR Multitasking -- rNOE -- steady‐state CEST; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.29109
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract: Purpose: To perform fast 3D steady‐state CEST (ss‐CEST) imaging using MR Multitasking. Methods: A continuous acquisition sequence with repetitive ss‐CEST modules was developed. Each ss‐CEST module contains a single‐lobe Gaussian saturation pulse, followed by a spoiler gradient and eight FLASH readouts (one "training line" + seven "imaging lines"). Three‐dimensional Cartesian encoding was used for k ‐space acquisition. Reconstructed CEST images were quantified with four‐pool Lorentzian fitting. Results: Steady‐state CEST with whole‐brain coverage was performed in 5.6 s per saturation frequency offset at the spatial resolution of 1.7 × 1.7 × 3.0 mm 3 . The total scan time was 5.5 min for 55 different frequency offsets. Quantitative CEST maps from multipool fitting showed consistent image quality across the volume. Conclusion: Three‐dimensional ss‐CEST with whole‐brain coverage can be done at 3 T within 5.5 min using MR Multitasking.