HAT‐Promoted Electrochemical Amination: C(sp2)−H/N−H Cross Dehydrogenative Coupling. Issue 5 (28th February 2023)

• Record Type: Journal Article
• Authors: Li, Heng; Chen, Jiajia; Zhang, Juncheng; Liu, Ping; Sun, Peipei
• Is Part Of: Advanced synthesis & catalysis. Volume 365:Issue 5(2023)
• Page Start: 747
• Page End: 752
• Publication Date: 2023-02-28
• Subjects: Electrochemical amination -- quinoxalin-2(1H)-ones -- hydrogen atom transfer -- transition metal- and oxidant-free -- TMSN3; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202201395
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A direct amination of quinoxalin‐2(1 H )‐ones via electrochemical C( sp 2 )−H/N−H cross dehydrogenative coupling was established by using TMSN3 as the hydrogen atom transfer (HAT) reagent. Remarkable features of this synthetic strategy include operational simplicity, transition metal‐ and chemical oxidant‐free conditions, and broad functional group tolerance. A wide range of primary, secondary amines and quinoxalinones are tolerated, giving the corresponding secondary and tertiary amination products in good to excellent yields. Abstract :