Cover Feature: Ability of Azathiacyclen Ligands To Stop Cu(Aβ)‐Induced Production of Reactive Oxygen Species: [3N1S] Is the Right Donor Set (Chem. Eur. J. 14/2023). Issue 14 (17th February 2023)

• Record Type: Journal Article
• Authors: Malikidogo, Kyangwi P.; Drommi, Marielle; Atrián‐Blasco, Elena; Hormann, Jan; Kulak, Nora; Esmieu, Charlène; Hureau, Christelle
• Is Part Of: Chemistry. Volume 29:Issue 14(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-17
• Subjects: Alzheimer's disease -- copper -- EPR -- macrocycles -- oxidative stress; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202300442
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Cu bound to Aβ (heads of the meteorites) produces reactive oxygen species (tails) that attack the brain. In the presence of the azamacrocyclic ligand 3N1S (the green belt), the Cu ions are removed by the ligand (the head of the meteorite is broken) and the ROS production is abolished (the tail disappears). Hence, the brain is safe behind its shield. In absence of 3N1S, the ROS produced by Cu(Aβ) attack the brain, which is "destroyed". More information can be found in the Research Article by C. Esmieu, C. Hureau, and co‐workers (DOI: 10.1002/chem.202203667 ).