Antiglutamate acid decarboxylase seropositive brain stem encephalitis. Issue 3 (10th March 2023)

• Record Type: Journal Article
• Authors: AlAbdulghafoor, Faye; Behbehani, Raed; Johar, Abbas; Alroughani, Raed
• Is Part Of: BMJ case reports. Volume 16:Issue 3(2023)
• Publication Date: 2023-03-10
• Subjects: neurology -- neuroopthalmology; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2022-254026
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : This is a case of a previously healthy female in her fourties presenting with a subacute presentation of bilateral horizontal gaze restriction, with bilateral lower motor facial palsy. The patient's daughter has type 1 diabetes. On investigation, the patient's MRI revealed a lesion in the dorsal medial pons. Cerebrospinal fluid analysis revealed albuminocytological dissociation, with a negative autoimmune panel. The patient was treated with intravenous immunoglobulin, and methylprednisolone for a total of 5 days and showed mild improvement. The patient had raised serum antiglutamic acid decarboxylase (anti-GAD) levels, and the final diagnosis of GAD seropositive brain stem encephalitis was made.