Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery. (1st January 2020)

• Record Type: Journal Article
• Authors: Ma, Qingming; Gao, Yang; Sun, Wentao; Cao, Jie; Liang, Yan; Han, Shangcong; Wang, Xinyu; Sun, Yong
• Is Part Of: Drug delivery. Volume 27:Number 1(2020)
• Page Start: 200
• Page End: 215
• Publication Date: 2020-01-01
• Subjects: Self-assembly -- drug delivery -- nanoparticles -- chitosan -- phospholipids; Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.1080/10717544.2020.1716878
• Languages: English
• ISSNs: 1071-7544

Abstract

Abstract: With the development of nanotechnology, self-assembled chitosan/phospholipid nanoparticles (SACPNs) show great promise in a broad range of applications, including therapy, diagnosis, in suit imaging and on-demand drug delivery. Here, a brief review of the SACPNs is presented, and its critical underlying formation mechanisms are interpreted with an emphasis on the intrinsic physicochemical properties. The state-of-art preparation methods of SACPNs are summarized, with particular descriptions about the classic solvent injection method. Then SACPNs microstructures are characterized, revealing the unique spherical core-shell structure and the drug release mechanisms. Afterwards, a comprehensive and in-depth depiction of their emerging applications, with special attention to drug delivery areas, are categorized and reviewed. Finally, conclusions and outlooks on further advancing the SACPNs toward a more powerful and versatile platform for investigations covering from fundamental understanding to developing multi-functional drug delivery systems are discussed.