Evaluation of Ocular Parameters in Adult Patients with Celiac Disease. (2nd January 2021)

• Record Type: Journal Article
• Authors: Hazar, Leyla; Oyur, Gülistan; Atay, Kadri
• Is Part Of: Current eye research. Volume 46:Number 1(2021)
• Page Start: 122
• Page End: 126
• Publication Date: 2021-01-02
• Subjects: Celiac disease -- antibody -- retinal nerve fiber layer -- anterior chamber; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; Ophthalmology -- Periodicals; 573.88
• DOI: 10.1080/02713683.2020.1780266
• Languages: English
• ISSNs: 0271-3683

Abstract

ABSTRACT: Purpose: To evaluate ophthalmic parameters in adult celiac patients Methods: This cross-sectional study included 31 celiac patients (58 eyes) and 25 healthy controls (50 eyes). Tear break up time (TBUT), schirmer test were measured; corneal thickness, anterior chamber parameters were obtained using scheimpflug camera; retinal nerve fiber layer thickness (RNFL) evaluated by using spectral domain optical cohorence tomography. Results: There were no statistically significant differences between the groups in terms of gender, age, and intraocular pressure ( p > .05). Schirmer's test results and TBUT were significantly lower in celiac patients ( p < .001, p < .001). Additionally, the superior RNFL was significantly thinner ( p = .017), nasal RNFL thicker ( p = .007), and anterior chamber depth larger ( p = .037) in celiac patients. The tissue transglutaminase 2 IgA antibody and superior RNFL were negatively correlated (r = −0.394, p = .012). The anterior chamber volume and anti-gliadin IgA antibody were positively correlated (r = 0.369 p = .027). Conclusion: Celiac disease affects Schirmer's test results, TBUT, segmental RNFL thickness, and anterior chamber parameters. Ocular parameters might be affected in celiac disease especially in the presence of high antibody titer.