Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms. (1st January 2020)

• Record Type: Journal Article
• Authors: Das, Mrinmoy; Stephen-Victor, Emmanuel; Bayry, Jagadeesh
• Is Part Of: Oncoimmunology. Volume 9:Number 1(2020)
• Publication Date: 2020-01-01
• Subjects: Basophil -- CD4+CD25+FoxP3+ regulatory T cell -- cancer -- immune evasion; Tregs; Th2 response; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2020.1773193
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Basophils play an important role in orienting Th2 immune response, and in the pathogenesis of allergic and inflammatory disorders. However, the mechanism by which basophils are kept in check remains unclear and hence we explored the role of regulatory T cells (Treg cells) in this process. We demonstrate that human Treg cells do not suppress rather induce activation of basophils, and promote Th2 responses by IL-3 and STAT5-dependent mechanism.