Cystic fibrosis transmembrane conductance regulator function in patients with chronic pancreatitis. Issue 8 (25th February 2022)

• Record Type: Journal Article
• Authors: Schlosser, Tobias; Fischer, Daniel; Büttner, Sandra; Blank, Valentin; Hoffmeister, Albrecht
• Other Names: Gouri. Adel section editor.
• Is Part Of: Medicine. Volume 101:Issue 8(2022)
• Publication Date: 2022-02-25
• Subjects: chronic pancreatitis -- cystic fibrosis -- nasal potential differences -- superfusion; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000028904
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Pathogenesis of chronic pancreatitis (CP) is still not entirely understood with many patients probably having more than 1 underlying etiology. Besides toxic-metabolic factors, genetics contribute to disease development. Mutations in cystic fibrosis transmembrane conductance regulator ( CFTR ) are shown to increase risk for CP. Activity of CFTR can easily be accessed in vivo by measurement of nasal potential difference (PD). Methods: We compared in this monocentric study 17 CP patients from the outpatient unit of our university hospital with 30 healthy controls regarding nasal PDs by using a superfusion protocol. Additionally, demographic and lifestyle data of all persons were recorded. Results: Seventeen patients (12% female, median age 48 years) with CP and 30 healthy volunteers (47% female, 25 years) were included in the study. Patients with CP had a significant higher proportion of CFTR dysfunction ( P = .04). Furthermore, demographics differed between the 2 groups with CP patients being older ( P < .001). There were differences in daily alcohol consumption ( P = .001) and smoking habits (smokers vs nonsmokers: P = .01, pack years: P = .002). Conclusions: PD measurement is an easily accessible way to show CFTR dysfunction as an etiological factor of CP. Cigarette smoking might impair CFTR function and therefore be 1 preventable cause of CP evolution.