A rare pediatric case of McCune–Albright syndrome with acute visual disturbance: Case report. Issue 6 (11th February 2022)

• Record Type: Journal Article
• Authors: Ninomiya, Hiroshi; Ozeki, Michio; Nozawa, Akifumi; Yasue, Shiho; Endo, Saori; Inuzuka, Masayuki; Obara, Natsuko; Mochizuki, Kiyofumi; Kawaguchi, Masaya; Kaneko, Yo; Ohe, Naoyuki; Aoki, Yoko; Matsuo, Masayuki; Iwama, Toru; Ohnishi, Hidenori
• Other Names: Saranathan. Maya section editor.
• Is Part Of: Medicine. Volume 101:Issue 6(2022)
• Publication Date: 2022-02-11
• Subjects: aneurysmal bone cyst -- case report -- fibrous dysplasia -- McCune–Albright syndrome -- orbital apex syndrome; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000028815
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: McCune–Albright syndrome (MAS) is a rare disorder characterized by clinical findings, which includes fibrous dysplasia (FD). FD is a benign tumor that leads to increased rates of bone fracture. In some MAS cases with FD, facial deformities, severe pain, and orbital neuropathies are complicated. Aneurysmal bone cyst (ABC) is a benign bone tumor and rare complication of FD. Patient concerns: A 9-year-old boy was admitted to our hospital because of acute visual disturbance. Diagnosis and interventions: The patient was clinically diagnosed as ABC complicated with MAS, and he underwent surgery. Outcomes: After the surgery, his sight became normal. Recurrence of ABC and visual disturbance was not observed in 3 years. Genetic analysis of a tissue sample from the ABC lesion by next-generation sequencing revealed a somatic activating GNAS mutation. Lessons: To the best of our knowledge, this is the first case report of MAS causing optic neuropathy complicated with ABC. ABC complicated with MAS is extremely rare, but it should be considered as a possible diagnosis in patients with acute visual loss and facial swelling. In addition, our case had OAS, which is an uncommon syndrome and a rare complication in ABC with MAS, and rapid decompression of the ABC was effective in improving the patient's eyesight.