Congenital Cytomegalovirus and Hepatic Failure: An Underrecognized Complication. Issue 2 (February 2022)

• Record Type: Journal Article
• Authors: Souder, J. Paige; Grimm, Erica; Pinninti, Swetha; Boppana, Suresh; Hsu, Evelyn; Horslen, Simon; Pacheco, M. Cristina; Kunz, Anjali; Sainato, Rebecca
• Is Part Of: Pediatric infectious disease journal. Volume 41:Issue 2(2022)
• Publication Date: 2022-02
• Subjects: hyperbilirubinemia -- cholestasis -- hepatitis -- liver failure -- term infant; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003381
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Congenital cytomegalovirus infection is the most common congenital infection. Although most infants with congenital cytomegalovirus infection are asymptomatic at birth, a subset will have readily apparent clinical and/or laboratory manifestations including hepatitis; progression to hepatic failure has not previously been described in term infants who initiated antiviral treatment shortly after birth. We present 2 term infants with congenital cytomegalovirus infection and hepatitis who progressed to hepatic failure despite initial laboratory improvement on therapy.