Cell-based immunotherapies in gynecologic cancers. Issue 1 (February 2022)

• Record Type: Journal Article
• Authors: Lang, Susan M.; Dorigo, Oliver
• Is Part Of: Current opinion in obstetrics and gynecology. Volume 34:Issue 1(2022)
• Publication Date: 2022-02
• Subjects: immune cell-targeted therapy -- immune cells -- ovarian cancer -- tumor microenvironment; Obstetrics -- Periodicals; Gynecology -- Periodicals; Genital Diseases, Female -- Indexes; Genital Diseases, Female -- Periodicals; Obstetrics -- Indexes; Obstetrics -- Periodicals; Review Literature -- Periodicals; 618.005
• DOI: 10.1097/GCO.0000000000000760
• Languages: English
• ISSNs: 1040-872X

Abstract

Abstract : Purpose of review: This review provides an update on recent developments in cell-based immunotherapy in gynecologic cancers. Recent findings: Chimeric antigen receptor (CAR) technology has made significant progress allowing now for not only expressing CARs on T-cells, but also on other immune effector cells, such as natural killer cells and macrophages. Cell-based vaccines have started to show promising results in clinical trials. Summary: Cell-based immunotherapies in gynecologic cancers continue to evolve with promising clinical efficacy in select patients.