Nonepileptic Electroencephalographic Correlates of Episodic Increases in Intracranial Pressure. Issue 2 (February 2022)

• Record Type: Journal Article
• Authors: Sheikh, Zubeda B.; Maciel, Carolina B.; Dhakar, Monica B.; Hirsch, Lawrence J.; Gilmore, Emily J.
• Is Part Of: Journal of clinical neurophysiology. Volume 39:Issue 2(2022)
• Publication Date: 2022-02
• Subjects: Electroencephalogram -- Brain injury -- Intracranial hypertension -- Neurocritical care -- Intracranial pressure -- Brain telemetry; Electroencephalography -- Periodicals; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electroencephalography; Periodicals; 612.805
• DOI: 10.1097/WNP.0000000000000750
• Languages: English
• ISSNs: 0736-0258

Abstract

Abstract : Purpose: Continuous EEG can potentially be used as real-time brain telemetry for the early detection of neurologic decline. Scant literature on EEG changes related to elevated intracranial pressure (ICP) limits its use in this context. Methods: Retrospective, observational case series of patients in whom we noted EEG changes correlating with a clinical concern for elevated ICP, measured or unmeasured. Results: We noted EEG changes of varying severity and duration correlating with either measured or unmeasured clinical concern for elevated ICP. In two patients with recurrent transient unresponsiveness (presumed from plateau waves), generalized rhythmic delta activity and attenuation of fast activity occurred 30 minutes before a clinical change. Elevated ICP in two patients, one related to progressive mass effect from infarctions, and the other to dialysis, correlated with generalized slowing and attenuation of fast activity up to 24 hours before clinical deterioration, leading to diffuse suppression. Two patients with intraventricular hemorrhage had cyclic patterns at ∼1 per minute and ∼6 per minute (similar frequency to described frequency of Lundberg B and C waves, respectively). Conclusions: Cyclic patterns and varying degrees of slowing and attenuation often preceded clinical deterioration associated with intracranial hypertension. Future systematic studies of EEG changes in this setting will facilitate early and noninvasive detection of elevated ICP.