Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature. Issue 2 (February 2022)

• Record Type: Journal Article
• Authors: Lyons, Lance J.; Wu, Kristi Y.; Baratz, Keith H.; Sit, Arthur J.
• Is Part Of: Cornea. Volume 41:Issue 2(2022)
• Publication Date: 2022-02
• Subjects: cornea -- edema -- honeycomb -- netarsudil -- ripasudil; Cornea -- Periodicals; Cornea -- Periodicals; Cornée -- Périodiques; 617.719
• DOI: 10.1097/ICO.0000000000002694
• Languages: English
• ISSNs: 0277-3740

Abstract

Abstract : Abstract: The Rho kinase inhibitor netarsudil is a recently approved therapeutic option for the management of increased intraocular pressure in the United States. Although phase 3 clinical trials noted corneal changes related to the medication—namely, nonvisually-significant corneal verticillata—descriptions of a unique form of cystic epithelial edema began to surface as netarsudil (and its sister drug ripasudil, approved in Japan) gained widespread use. This series adds 3 new cases and reviews the current literature on this unique side effect.