Hypertensive disorders of pregnancy increase the risk of future menopausal hot flashes in Japanese women: results from the Japan Nurses' Health Study. Issue 2 (February 2022)

• Record Type: Journal Article
• Authors: Ri, Moyo; Hayashi, Kunihiko; Kurabayashi, Takumi; Lee, Jung Su; Ideno, Yuki; Nagai, Kazue; Yasui, Toshiyuki; Kubota, Toshihiro; Takamatsu, Kiyoshi
• Is Part Of: Menopause. Volume 29:Issue 2(2022)
• Publication Date: 2022-02
• Subjects: Hypertensive disorders of pregnancy -- Japan Nurses' Health Study -- Menopausal hot flashes; Menopause -- Periodicals; 618.175005
• DOI: 10.1097/GME.0000000000001889
• Languages: English
• ISSNs: 1072-3714

Abstract

Abstract: Objective: We aimed to investigate whether hypertensive disorders of pregnancy (HDP) are associated with problematic hot flashes in Japanese women. Methods: In this study, we included participants in the Japan Nurses' Health Study who were women aged 41 to 55 years at baseline, parous, and completed a 4-year follow-up questionnaire. The main outcome was self-reported problematic hot flashes. At the 4-year follow-up survey, we investigated hot flashes using the Climacteric Symptom Checklist for Japanese Women, which was developed by a subcommittee of the Japan Society of Obstetrics and Gynecology. Results: At the baseline survey, of the 4, 627 women included in the analysis, 610 (13.2%) reported a history of HDP. At the 4-year follow-up survey, 394 women (8.5%) reported problematic hot flashes, 529 (11.4%) were diagnosed with premenopausal hypertension, and 2, 389 (51.5%) were postmenopausal. Multivariable logistic regression analysis revealed a multivariable-adjusted odds ratio (95% confidence interval) of problematic hot flashes for women with a history of HDP of 1.42 (1.04-1.94), compared with women without this history. Among women without premenopausal hypertension, the odds ratio increased to 1.55 (1.10-2.19) among women with HDP as compared with those without these disorders. Conclusions: In this prospective study, we found that women with a history of HDP have a significantly increased risk of problematic hot flashes, compared with their counterparts without a history of HDP.