CT texture analysis compared to Positron Emission Tomography (PET) and mutational status in resected melanoma metastases. Issue 131 (October 2020)

• Record Type: Journal Article
• Authors: Olthof, Susann-Cathrin; Krumm, Patrick; Weichold, Oliver; Eigentler, Thomas; Bösmüller, Hans; la Fougère, Christian; Pfannenberg, Christina; Martus, Peter; Klumpp, Bernhard
• Is Part Of: European journal of radiology. Issue 131(2020)
• Publication Date: 2020-10
• Subjects: BRAF B-RAF gene -- c-KIT Proto-Oncogene c-Kit -- FOV Field of View -- i.v. Intravenous -- kv Kilovolt -- LA Largest Diameter -- MATV Metabolic Active Tumour Volume -- MPP Mean Values of Positive Pixels -- MBq Mega Becquerel -- mAs milli Ampere second -- NRAS NRAS gene -- 18F-FDG PET/CT Flurodeoxyglucose Positron emission tomography–computed tomography -- IQR Interquartile range -- ROI Region of Interest -- SD Standard Deviation -- SUV Standard Uptake Value -- TLG Tumour Lesion Glycolysis -- UPP Uniformity of Distribution of Positive Pixels -- VOI Volume of interest -- wt Wildtype; Melanoma -- CT Texture Analysis -- Tumour Heterogeneity -- 18F-FDG PET/CT; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2020.109242
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: SUVpeak correlated with CT parameter "attenuation standard deviation". 18 F-FDG PET/CT cannot be replaced by CT texture analysis alone. Metabolic and CT texture parameters did not predict mutational status in our cohort. Histopathology for mutational status cannot be replaced by multimodal imaging. Abstract: Purpose: To evaluate the potential of CT texture analysis parameters and metabolic characteristics of melanoma metastases in 18 F- FDG PET/CT to predict relevant mutations of tumour cells for targeted therapy in metastatic melanoma patients in correlation with histopathologic specimen. Material and methods: 66 melanoma patients, examined with contrast-enhanced 18 F-FDG PET/CT before scheduled metastasectomy without any prior systemic therapy, were included in this single-centre retrospective analysis under IRB waiver. The largest, resected metastasis in each patient was assessed with CT texture analysis and semiquantitative 18 F-FDG PET parameters. Correlation between imaging parameters and histopathological mutations (BRAF- and NRAS- genes) were calculated. Results: Attenuation standard deviation (SD) within target lesion indicated a weak correlation with its SUVpeak (rho −0.292, p 0.017). However, no correlation between CT texture analysis, metabolic 18 F-FDG PET parameters and tumour cell mutation could be established. Conclusion: CT texture parameters cannot replace the diagnostic value of 18 F- FDG PET/CT for metabolic information in melanoma patients. Discrimination between BRAF- and NRAS mutation status was not feasible with CT texture analysis in this exploratory study.