Outcomes between intensity‐modulated radiation therapy versus 3D‐conformal in early stage glottic cancer. Issue 11 (12th August 2021)

• Record Type: Journal Article
• Authors: Amini, Arya; Morgan, Rustain; Meyer, Elisabeth; Fakhoury, Kareem; Ladbury, Colton; Bickett, Thomas; McDermott, Jessica D.; Stokes, William; Karam, Sana D.
• Is Part Of: Head & neck. Volume 43:Issue 11(2021)
• Page Start: 3393
• Page End: 3403
• Publication Date: 2021-08-12
• Subjects: 3D‐conformal therapy -- glottis cancer -- intensity‐modulated radiation therapy -- larynx cancer -- radiation -- SEER‐Medicare; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.26841
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The purpose of this study is to evaluate practice patterns and outcomes between intensity‐modulated radiation therapy (IMRT) and 3D‐conformal radiation (3D‐CRT) in early stage glottic cancer. Methods: The linked Surveillance, Epidemiology, and End Results (SEER)‐Medicare database was used to identify and compare patient and disease profiles, mortality, and toxicity in patients with T1‐2 larynx cancer undergoing definitive radiation (RT). Results: A total of 1520 patients underwent definitive radiation with 3D‐CRT ( n = 1309) or IMRT ( n = 211). Non‐white race, those with a Charlson Comorbidity Index ≥2, T2 disease, and those treated at community practices were more likely to undergo IMRT. Rates of IMRT increased from 2006 to 2015, while relative rates of 3D‐CRT decreased. Two‐year CSS was superior with 3D‐CRT (hazard ratio [HR], 0.38; 95% confidence interval [CI], 0.22–0.65; p < 0.001). There was no difference in OS between 3D‐CRT and IMRT ( p = 0.119). Conclusions: Patients receiving 3D‐CRT had improved CSS compared to IMRT with no difference in OS.