E‐cadherin deregulation in breast cancer. Issue 11 (16th April 2020)

• Record Type: Journal Article
• Authors: Corso, Giovanni; Figueiredo, Joana; De Angelis, Simone Pietro; Corso, Federica; Girardi, Antonia; Pereira, Joana; Seruca, Raquel; Bonanni, Bernardo; Carneiro, Patricia; Pravettoni, Gabriella; Guerini Rocco, Elena; Veronesi, Paolo; Montagna, Giacomo; Sacchini, Virgilio; Gandini, Sara
• Is Part Of: Journal of cellular and molecular medicine. Volume 24:Issue 11(2020)
• Page Start: 5930
• Page End: 5936
• Publication Date: 2020-04-16
• Subjects: breast cancer -- breast cancer metastases -- breast cancer prognosis -- breast cancer survival -- E‐cadherin; Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.15140
• Languages: English
• ISSNs: 1582-1838

Abstract

Abstract: E‐cadherin protein ( CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.