Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 5: Lincosamides: lincomycin. (26th October 2021)

• Record Type: Journal Article
• Authors: Koutsoumanis, Konstantinos; Allende, Ana; Alvarez‐Ordóñez, Avelino; Bolton, Declan; Bover‐Cid, Sara; Chemaly, Marianne; Davies, Robert; De Cesare, Alessandra; Herman, Lieve; Hilbert, Friederike; Lindqvist, Roland; Nauta, Maarten; Ru, Giuseppe; Simmons, Marion; Skandamis, Panagiotis; Suffredini, Elisabetta; Andersson, Dan I; Bampidis, Vasileios; Bengtsson‐Palme, Johan; Bouchard, Damien; Ferran, Aude; Kouba, Maryline; López Puente, Secundino; López‐Alonso, Marta; Nielsen, Søren Saxmose; Pechová, Alena; Petkova, Mariana; Girault, Sebastien; Broglia, Alessandro; Guerra, Beatriz; Innocenti, Matteo Lorenzo; Liébana, Ernesto; López‐Gálvez, Gloria; Manini, Paola; Stella, Pietro; Peixe, Luisa;
• Is Part Of: EFSA journal. Volume 19:Number 10(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-26
• Subjects: lincomycin -- antimicrobial resistance -- sub‐inhibitory concentration -- Feed Antimicrobial Resistance Selection Concentration (FARSC) -- growth promotion -- yield increase -- food‐producing animals; Food -- Europe -- Safety measures -- Periodicals; Food Safety; Food -- Safety measures; Europe; Periodicals; Periodicals; Fulltext; Government Publications, International; Internet Resources; Periodicals; Periodicals; 363.19209405
• DOI: 10.2903/j.efsa.2021.6856
• Languages: English
• ISSNs: 1831-4732

Abstract

Abstract: The specific concentrations of lincomycin in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of lincomycin in feed that showed to have an effect on growth promotion/increased yield were reported. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for lincomycin.