Should trigeminal neuralgia be considered a clinically isolated syndrome?. (April 2023)

• Record Type: Journal Article
• Authors: Tohyama, Sarasa; Oh, Jiwon; Timm, Makenna; Cheng, Joshua C; Halawani, Aisha; Mikulis, David J; Solomon, Andrew J; Hodaie, Mojgan
• Is Part Of: Multiple sclerosis. Volume 29:Number 4/5(2023)
• Page Start: 637
• Page End: 641
• Publication Date: 2023-04
• Subjects: Trigeminal neuralgia -- multiple sclerosis -- clinically isolated syndrome -- diagnosis -- diagnostic criteria -- MRI -- lesion; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585221149886
• Languages: English
• ISSNs: 1352-4585

Abstract

The association between trigeminal neuralgia (TN) and multiple sclerosis (MS) is well established. Many MS patients with TN have magnetic resonance imaging (MRI) evidence of a symptomatic demyelinating lesion. Although infratentorial presentations are included in the diagnostic criteria for MS, there remains confusion in clinical practice as to whether TN should be considered a clinically isolated syndrome for the application of McDonald criteria. In this case series, we discuss this diagnostic quandary in patients presenting with TN and additional MRI findings suggestive of MS and highlight the unmet need for data in such patients to optimally guide their care.