Efficacy of argon‐helium cryoablation and its effects on immune function of patients with neck malignant tumours. (15th October 2020)

• Record Type: Journal Article
• Authors: Zheng, Zheng; Zhao, Yingchun; An, Yonghui; Li, Na; Bo, Changwen; Ma, Wenhua; Guo, Ying; Zou, Changpeng; Tian, Bo; Zhang, Sujing
• Is Part Of: Clinical otolaryngology. Volume 46:Number 1(2021)
• Page Start: 206
• Page End: 212
• Publication Date: 2020-10-15
• Subjects: argon‐helium cryoablation -- clinical efficacy -- immune function -- malignant tumour -- neck -- stereotactic radiotherapy; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1111/coa.13648
• Languages: English
• ISSNs: 1749-4478

Abstract

Abstract: Objectives: Our study aimed to investigate the clinical efficacy of argon‐helium cryoablation and its effects on the immune function of patients with neck malignant tumours. Design: Retrospective study. Setting: Single‐institution academic tertiary care centre. Methods: Totally, 180 patients harbouring head and neck malignant tumours were divided into the argon‐helium cryoablation group (n = 150) and the radiotherapy group (n = 50). The efficacy of the two groups was compared, and the immune function was observed. Results: The short‐term clinical effect of the argon‐helium cryoablation group was significantly higher than that of the radiotherapy group ( P < .05). After treatment, the CD3+, CD4+, CD8+ and CD4+/CD8+ of the argon‐helium cryoablation group were significantly better than those of the radiotherapy group ( P < .001). The results of TNF‐α, IL‐1 β and CRP in the argon‐helium cryoablation group were significantly better than that in the radiotherapy group ( P < .001). Conclusion: Argon‐helium cryoablation could effectively improve the immune function, 5‐year survival rate and local remission rate.