Metal‐Free Photoinduced Deformylative Minisci‐Type Reaction. Issue 6 (18th February 2022)

• Record Type: Journal Article
• Authors: Wang, Xinxin; Shao, Xin; Cao, Zhu; Wu, Xinxin; Zhu, Chen
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 6(2022)
• Page Start: 1200
• Page End: 1204
• Publication Date: 2022-02-18
• Subjects: metal-free -- Minisci reaction -- photochemistry -- heteroarenes -- radical reactions; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202101447
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A metal‐free deformylative Minisci‐type reaction is disclosed by using aliphatic aldehydes as alkyl radical precursors. The reaction proceeds via a sequence of hydrogen atom abstraction (HAA) from aldehyde and decarbonylation under mild photochemical conditions. The transformation offers many advantages including good regioselectivity, broad substrate scope, and easy operation. The reaction is also amenable to late‐stage functionalization of complex heteroarenes, and can be readily performed on gram scale. Abstract :