The testing of saliva samples for HIV-1 antibodies: reliability in a non-clinic setting. Issue 1 (February 1993)

• Record Type: Journal Article
• Authors: Hunt, A J; Connell, J; Christofinis, G; Parry, J V; Weatherburn, P; Hickson, F C; Coxon, A P; Davies, P M; McManus, T J; Sutherland, S
• Is Part Of: Sexually transmitted infections. Volume 69:Issue 1(1993)
• Page Start: 29
• Page End: 30
• Publication Date: 1993-02
• Subjects: Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sti.69.1.29
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : AIMS--To assess the reliability of saliva samples as a means of testing for HIV-antibodies outside clinic settings. METHODS--Men taking part in a non-clinic longitudinal study of homosexually active men provided samples of saliva and blood. Sera were screened using a competitive ELISA (Wellcozyme) and positive sera were confirmed by an indirect ELISA (Abbott). Saliva samples were screened either using an IgG captive radioimmunoassay or an amplified ELISA. RESULTS--A total of 534 paired saliva and blood samples were tested. Overall sensitivity was 96.2% and specificity was 100%. None of the saliva tests were falsely positive for HIV-1 antibodies. CONCLUSIONS--HIV-1 saliva tests can reliably be used in a non-clinic or field setting. However, if results are to be given to respondents, it is necessary to offer adequate counselling and consider the mechanisms for referral and follow-up for those that are found to be HIV-1 antibody positive.