Exosome‐based intercellular communication in female reproductive microenvironments. Issue 11 (15th April 2019)

• Record Type: Journal Article
• Authors: Ranjbaran, Ali; Latifi, Zeinab; Nejabati, Hamid Reza; Abroon, Sina; Mihanfar, Aynaz; Sadigh, Aydin Raei; Fattahi, Amir; Nouri, Mohammad; Raffel, Nathalie
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 11(2019:Nov.)
• Page Start: 19212
• Page End: 19222
• Publication Date: 2019-04-15
• Subjects: cell communication -- embryology -- exosome -- female reproduction; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28668
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Different strategies are applied for cellular cross‐talk and organization in multicellular organisms. Exosomes are a homogenous population of biological nanoparticles (30–100 nm), originated from multivesicular bodies. The exosomes (Exos) could regulate and affect both cellular physiology and pathophysiology in various organs, such as the female reproductive tract, by altering gene pathways and/or epigenetic programming. Besides, engineered Exos have the potential to be used as a novel drug and gene delivery tools. Here in this review, we discussed various aspects of exosome‐based intercellular communication in female reproductive microenvironments. Furthermore, we addressed the findings and issues related to Exos in reproductive biology to give a better view of the involved molecular mechanisms. Moreover, clinical applications of the Exos and their isolation source/methods have been considered to throw some light on the progression of new biological, diagnostic, and therapeutic approaches in clinical embryology. Abstract : Here in this review, we discussed various aspects of exosome‐based intercellular communication in female reproductive microenvironments. Furthermore, we addressed the findings and issues related to exosomes (Exos) in reproductive biology to give a better view of the involved molecular mechanisms. Moreover, clinical applications of the Exos and their isolation source/methods have been considered to throw some light on the progression of new biological, diagnostic, and therapeutic approaches in clinical embryology.