Transcription factor 7‐like 2‐associated signaling mechanism in regulating cementum generation by the NF‐κB pathway. Issue 11 (29th April 2019)

• Record Type: Journal Article
• Authors: Zhao, Zifan; Dai, Jing; Yin, Chengcheng; Wang, Xuzhu; Wang, Jinyang; Jia, Xiaoshi; Zhao, Qin; Fu, Hui; Zhang, Yufeng; Xia, Haibin
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 11(2019:Nov.)
• Page Start: 20790
• Page End: 20800
• Publication Date: 2019-04-29
• Subjects: cementoblast -- dental cementum -- NF‐κB signal pathway -- signal transduction -- Tcf7l2; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28685
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Cementum regeneration is an important and challenging stage in periodontal tissue engineering and regeneration. Pathosis of the periodontium, including cementum, is important in precision diagnosis and obstinate treatment of systemic diseases, such as diabetes, leukemia, and Acquired Immune Deficiency Syndrome. Here, we found that during periodontium development, transcription factor 7‐like 2 (Tcf7l2) was widely expressed in the periodontium and dental sac. In mouse cementoblast cell line (OCCM‐30), the activation of NF‐κB and cementoblast mineralization was significantly reduced when Tcf7l2 gene was silenced. Moreover, Tcf7l2 has a positive effect on NF‐κB and cementoblast mineralization. Therefore, Tcf7l2 promotes cementum formation through the NF‐κB pathway. In addition, we found a decreased expression of phosphorylated p65 and a thin layer of cementum in Tcf7l2 fl/fl mice. These results suggest that Tcf7l2, which accelerates cementum formation by activating NF‐κB, has great potential in the treatment of periodontitis and provide guidance for periodontal tissue regeneration. Abstract : During periodontium development, Tcf7l2 was widely expressed in the periodontium and dental sac. Tcf7l2 promotes cementum formation through the NF‐κB pathway in vitro and found the decreased expression of phosphorylated p65 and a thin layer of cementum in Tcf7l2 fl/fl mice.