Role of two‐component regulatory systems in intracellular survival of Mycobacterium tuberculosis. Issue 8 (26th April 2019)

• Record Type: Journal Article
• Authors: Li, Xue; Lv, Xi; Lin, Yanping; Zhen, Junfeng; Ruan, Cao; Duan, Wei; Li, Yue; Xie, Jianping
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 8(2019)
• Page Start: 12197
• Page End: 12207
• Publication Date: 2019-04-26
• Subjects: histidine kinase -- intracellular survival -- Mycobacterium tuberculosis -- response regulator -- two‐component systems; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28792
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: The typical two‐component regulatory systems (TCSs), consisting of response regulator and histidine kinase, play a central role in survival of pathogenic bacteria under stress conditions such as nutrient starvation, hypoxia, and nitrosative stress. A total of 11 complete paired two‐component regulatory systems have been found in Mycobacterium tuberculosis, including a few isolated kinase and regulatory genes. Increasing evidence has shown that TCSs are closely associated with multiple physiological process like intracellular persistence, pathogenicity, and metabolism. This review gives the two‐component signal transduction systems in M. tuberculosis and their signal transduction roles in adaption to the environment. Abstract : Increasing evidence has shown that TCSs are closely associated with multiple physiological process like intracellular persistence, pathogenicity, and metabolism. This review gives the two‐component signal transduction systems in Mycobacterium tuberculosis and their signal transduction roles in adaption to the environment.