Functional Ultrasound Speckle Decorrelation‐Based Velocimetry of the Brain. Issue 18 (26th July 2020)

• Record Type: Journal Article
• Authors: Tang, Jianbo; Postnov, Dmitry D.; Kilic, Kivilcim; Erdener, Sefik Evren; Lee, Blaire; Giblin, John T.; Szabo, Thomas L.; Boas, David A.
• Is Part Of: Advanced science. Volume 7:Issue 18(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-26
• Subjects: brain imaging -- cerebral blood flow velocity -- field autocorrelation function -- functional ultrasound velocimetry; Science -- Periodicals; 505
• DOI: 10.1002/advs.202001044
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: A high‐speed, contrast‐free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first‐order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power‐Doppler‐ and Color‐Doppler‐based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high‐frequency noise. Abstract : A high‐speed, contrast‐free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first‐order ultrasound field signal temporal autocorrelation function. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is capable of imaging blood flow velocity changes during whisker stimulation in awake mice.