Target highlights in CASP14: Analysis of models by structure providers. Issue 12 (10th October 2021)

• Record Type: Journal Article
• Authors: Alexander, Leila T.; Lepore, Rosalba; Kryshtafovych, Andriy; Adamopoulos, Athanassios; Alahuhta, Markus; Arvin, Ann M.; Bomble, Yannick J.; Böttcher, Bettina; Breyton, Cécile; Chiarini, Valerio; Chinnam, Naga babu; Chiu, Wah; Fidelis, Krzysztof; Grinter, Rhys; Gupta, Gagan D.; Hartmann, Marcus D.; Hayes, Christopher S.; Heidebrecht, Tatjana; Ilari, Andrea; Joachimiak, Andrzej; Kim, Youngchang; Linares, Romain; Lovering, Andrew L.; Lunin, Vladimir V.; Lupas, Andrei N.; Makbul, Cihan; Michalska, Karolina; Moult, John; Mukherjee, Prasun K.; Nutt, William (Sam); Oliver, Stefan L.; Perrakis, Anastassis; Stols, Lucy; Tainer, John A.; Topf, Maya; Tsutakawa, Susan E.; Valdivia‐Delgado, Mauricio; Schwede, Torsten;
• Other Names: Moult John guestEditor.; Kryshtafovych Andriy guestEditor.
• Is Part Of: Proteins. Volume 89:Issue 12(2021)
• Page Start: 1647
• Page End: 1672
• Publication Date: 2021-10-10
• Subjects: CASP -- community‐wide experiment -- cryo‐EM -- protein structure prediction -- X‐ray crystallography; Proteins -- Periodicals; Proteins -- Periodicals; 572.6
• DOI: 10.1002/prot.26247
• Languages: English
• ISSNs: 0887-3585

Abstract

Abstract: The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three‐dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modeled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically‐relevant properties of proteins.