4‐(Dimethylamino)pyridine‐Catalyzed (3+2) Annulation of Pyrazoledione‐Derived Morita–Baylis–Hillman Carbonates with 2‐Arylideneindane‐1, 3‐Diones: An Access to Dispirocyclic Compounds. Issue 6 (4th February 2022)

• Record Type: Journal Article
• Authors: Liao, Jianning; Xu, Jiaqing; Wu, Yongjun; Hou, Yuxia; Guo, Hongchao
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 6(2022)
• Page Start: 1074
• Page End: 1079
• Publication Date: 2022-02-04
• Subjects: DMAP -- annulation -- MBH carbonate -- pyrazoledione -- spirocyclic compounds; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202101251
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A 4‐(dimethylamino)pyridine‐catalyzed (3+2) annulation of pyrazoledione‐derived Morita–Baylis–Hillman (MBH) carbonates with 2‐arylideneindane‐1, 3‐diones has been developed to afford various multifunctional spiropyrazole derivatives in 16–99% yields with 3:2–>20:1 diastereoselectivities. As a type of Lewis‐base receptor, the pyrazoledione‐derived MBH carbonates will function as a key substrate in organocatalyzed annulation reactions for diverse syntheses of pyrazolinone‐containing dispirocyclic compounds. Abstract :