Whole‐brain high‐resolution metabolite mapping with 3D compressed‐sensing SENSE low‐rank 1H FID‐MRSI. (1st October 2021)

• Record Type: Journal Article
• Authors: Klauser, Antoine; Klauser, Paul; Grouiller, Frédéric; Courvoisier, Sébastien; Lazeyras, François
• Is Part Of: NMR in biomedicine. Volume 35:Number 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-01
• Subjects: 3D magnetic resonance spectroscopic imaging -- acceleration -- brain metabolites -- compressed sensing -- high‐field MRI -- low rank -- SENSE -- whole‐brain spectroscopy; Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.4615
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract : There is a growing interest in the neuroscience community to map the distribution of brain metabolites in vivo. Magnetic resonance spectroscopic imaging (MRSI) is often limited by either a poor spatial resolution and/or a long acquisition time, which severely restricts its applications for clinical and research purposes. Building on a recently developed technique of acquisition‐reconstruction for 2D MRSI, we combined a fast Cartesian 1 H‐FID‐MRSI acquisition sequence, compressed‐sensing acceleration, and low‐rank total‐generalized‐variation constrained reconstruction to produce 3D high‐resolution whole‐brain MRSI with a significant acquisition time reduction. We first evaluated the acceleration performance using retrospective undersampling of a fully sampled dataset. Second, a 20 min accelerated MRSI acquisition was performed on three healthy volunteers, resulting in metabolite maps with 5 mm isotropic resolution. The metabolite maps exhibited the detailed neurochemical composition of all brain regions and revealed parts of the underlying brain anatomy. The latter assessment used previous reported knowledge and a atlas‐based analysis to show consistency of the concentration contrasts and ratio across all brain regions. These results acquired on a clinical 3 T MRI scanner successfully combined 3D 1 H‐FID‐MRSI with a constrained reconstruction to produce detailed mapping of metabolite concentrations at high resolution over the whole brain, with an acquisition time suitable for clinical or research settings. Abstract : A novel acquisition‐reconstruction scheme, combining FID‐MRSI with a compressed‐sensing sensitivity‐encoding low‐rank model, makes possible 3D spectroscopic imaging of the whole human brain in high resolution on a 3 T system. Following 20 min acquisition, the resulting metabolic maps reflect the detailed neurochemical composition of all brain regions.