Alfacalcidol as a modulator of growth of low grade non-Hodgkin's lymphomas. Issue 6503 (26th October 1985)

• Record Type: Journal Article
• Authors: Cunningham, D; Gilchrist, N L; Cowan, R A; Forrest, G J; McArdle, C S; Soukop, M
• Is Part Of: BMJ. Volume 291:Issue 6503(1985)
• Page Start: 1153
• Page End: 1155
• Publication Date: 1985-10-26
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.291.6503.1153
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Ten patients with low grade non-Hodgkin's lymphoma (seven follicular small cleaved and three small lymphocytic) were treated with 1 microgram oral alfacalcidol (1 alpha-hydroxycholecalciferol) daily. Of the seven patients with lymphomas of follicular small cleaved subtype, one achieved complete and three partial remission, whereas none of three patients with small lymphocytic lymphomas responded. In seven of the 10 patients, 1, 25(OH)2D3 receptors were measured in tissue from lymph nodes, and a positive correlation between the presence and amount of receptor and response to alfacalcidol was found. These preliminary data suggest that alfacalcidol has appreciable antitumour activity in low grade non-Hodgkin's lymphomas.