Glycemic control is associated with dyslipidemia over time in youth with type 2 diabetes: The SEARCH for diabetes in youth study. Issue 7 (15th August 2021)

• Record Type: Journal Article
• Authors: Brady, Ryan P.; Shah, Amy S.; Jensen, Elizabeth T.; Stafford, Jeanette M.; D'Agostino, Ralph B.; Dolan, Lawrence M.; Knight, Lisa; Imperatore, Giuseppina; Turley, Christine B.; Liese, Angela D.; Urbina, Elaine M.; Lawrence, Jean M.; Pihoker, Catherine; Marcovina, Santica; Dabelea, Dana
• Is Part Of: Pediatric diabetes. Volume 22:Issue 7(2021)
• Page Start: 951
• Page End: 959
• Publication Date: 2021-08-15
• Subjects: dyslipidemia -- type 2 diabetes -- youth; Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.13253
• Languages: English
• ISSNs: 1399-543X

Abstract

Abstract: Background: Dyslipidemia has been documented in youth with type 2 diabetes. There is a paucity of studies examining dyslipidemia over time in youth with type 2 diabetes and associated risk factors. Objective: To evaluate lipids at baseline and follow‐up and associated risk factors in youth with type 2 diabetes. Methods: We studied 212 youth with type 2 diabetes at baseline and after an average of 7 years of follow‐up in the SEARCH for Diabetes in Youth Study. Abnormal lipids were defined as high‐density lipoprotein cholesterol (HDL‐C) < 35, low‐density lipoprotein cholesterol (LDL‐C) > 100, or triglycerides >150 (all mg/dl). We evaluated participants for progression to abnormal lipids (normal lipids at baseline and abnormal at follow‐up), regression (abnormal lipids at baseline and normal at follow‐up), stable normal, and stable abnormal lipids over time for HDL‐C, LDL‐C, and triglycerides. Associations between hemoglobin A1c (HbA1c) and adiposity over time (area under the curve [AUC]) with progression and stable abnormal lipids were evaluated. Results: HDL‐C progressed, regressed, was stable normal, and stable abnormal in 12.3%, 11.3%, 62.3%, and 14.2% of participants, respectively. Corresponding LDL‐C percentages were 15.6%, 12.7%, 42.9%, and 28.8% and triglycerides were 17.5%, 10.8%, 55.7%, and 16.0%. Each 1% increase in HbA1c AUC was associated with a 13% higher risk of progression and stable abnormal triglycerides and a 20% higher risk of progression and stable abnormal LDL‐C. Higher adiposity AUC was marginally (p = 0.049) associated with abnormal HDL‐C. Conclusions: Progression and stable abnormal LDL‐C and triglycerides occur in youth with type 2 diabetes and are associated with higher HbA1c.