Asthma–chronic obstructive pulmonary disease overlap in China: prevalence, associated factors and comorbidities in middle-aged and older adults. (2nd April 2020)

• Record Type: Journal Article
• Authors: Song, Peige; Zha, Mingming; Xia, Wei; Zeng, Chunxian; Zhu, Yajie
• Is Part Of: Current medical research and opinion. Volume 36:Number 4(2020)
• Page Start: 667
• Page End: 675
• Publication Date: 2020-04-02
• Subjects: Asthma–chronic obstructive pulmonary disease overlap -- prevalence -- epidemiology -- survey; Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1080/03007995.2020.1722082
• Languages: English
• ISSNs: 0300-7995

Abstract

Abstract: Background: Asthma–COPD overlap (ACO) is a persistent airflow limitation with features of both asthma and chronic obstructive pulmonary disease (COPD). No studies have explored the prevalence of ACO at the national level in China. Objective: In this study, we aimed to estimate the prevalence of ACO and to assess the associated factors and comorbidities of ACO in middle-aged and older Chinese. Methodology: Participants aged 45 years and over in a nationally representative investigation – the China Health and Retirement Longitudinal Study (CHARLS) in 2011 – were included. ACO was defined as a dual self-reported physician diagnosis of asthma and COPD. The prevalence of ACO was demonstrated across different characteristic groups. The potentially associated factors and comorbidities were examined by logistic regressions. Results: The prevalence of ACO was 2.22% in general middle-aged and older Chinese. The relative prevalence of ACO to asthma was 62.53% and that to COPD was 21.99%. Older age (≥70 years), Northwest China residence, smoking (former and current) and former alcohol drinking were associated with a higher risk of ACO. Comorbidities of ACO included stomach or other digestive disease, kidney disease, cardiovascular disease, and arthritis or rheumatism. Conclusions: ACO was a prevalent condition in middle-aged and older Chinese. Better management and more research on ACO are needed.