A porous Sr(II)-organic framework for 5-fluorouracil delivery and anti-cancer activity against human melanoma cells. Issue 12 (1st December 2020)

• Record Type: Journal Article
• Authors: Feng, Xi-En; Zhu, Tian-Tian
• Is Part Of: Inorganic and nano-metal chemistry. Volume 50:Issue 12(2020)
• Page Start: 1302
• Page End: 1307
• Publication Date: 2020-12-01
• Subjects: Sr(II)-framework -- porous structure -- 5-Fu delivery -- melanoma; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: 10.1080/24701556.2020.1748057
• Languages: English
• ISSNs: 2470-1556

Abstract

Abstract: A new Sr(II)-based metal organic framework (MOF) formulated as [Sr(HTATB)(H2 O)2 ](DMF)4 (1 ) has been prepared by reaction of Sr(NO3 )2 with the rigid tricarboxylic acid linker 4, 4′, 4″-s-triazine-2, 4, 6-triyltribenzoic acid (H3 TATB) in a mixed solvent of N, N-dimethylformamide (DMF) and water. Complex 1 has been characterized by powder X-ray diffraction (PXRD), elemental analysis (EA) and single crystal X-ray diffraction (SCXRD). In light of its large inner spaces as well as widely distributed open metal sites, the guest-free 1 (1a ) has been used as a crystalline vessel for delivering small-molecule chemotherapeutics such as 5-fluorouracil (5-Fu), which exhibits an outstanding loading capacity around 36.48 wt%. Furthermore, the cumulative release value of 5-Fu at 48 h was about 96.5% in phosphate buffer saline (PBS). In addition, the 3-(4, 5-dimethyl-2-thiazolyl)−2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay was employed to evaluate the in vitro cytotoxicity of the carrier 5-Fu loaded 1a against the human melanoma cell lines.