Layered bifuncational Co(II) coordination polymer for photodegradation of organic dyes and anti-osteoporosis activity by activating wnt/β-catenin/PPARγ pathway in BMSCs. Issue 12 (1st December 2020)

• Record Type: Journal Article
• Authors: Cheng, Zhi-Yong; Ji, Ming; Yang, Yong; Wu, Xue-Jian
• Is Part Of: Inorganic and nano-metal chemistry. Volume 50:Issue 12(2020)
• Page Start: 1239
• Page End: 1247
• Publication Date: 2020-12-01
• Subjects: Coordination polymer -- layered network -- {Co2(CO2)4} cluster -- dye degradation -- molecular docking; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: 10.1080/24701556.2020.1745835
• Languages: English
• ISSNs: 2470-1556

Abstract

Abstract: A new coordination polymer (CP) [Co(HTATB)(H2 O)](DMF)2 (1, DMF = N, N-dimethylformamide) based on the {Co2 (CO2 )4 } binuclear secondary building unit (SBU) has been successfully prepared by using a light-harvesting triphenylamine type organic ligand 4, 4′, 4″-s-triazine-2, 4, 6-triyltribenzoic acid (H3 TATB). Furthermore, complex 1 has significant photocatalytic activity under visible light for the degradation of organic dyes such as rhodamine B (RhB), methylene blue (MB) as well as methyl orange (MO) assisted by H2 O2 . Furthermore, the anti-osteoporosis activity of complex 1 was evaluated. First, the inhibitory effect of complex 1 on the BMSCs apoptosis was measured by Annexin V-FITC/PI method. Then, the RT-PCR was performed to detect the relative expressions level of wnt/β-catenin and PPARγ after complex 1 treatment. The hypothesis that arises from the experimental observation has been further investigated by using molecular docking simulation, where the possible binding interactions between the ligand and Wnt protein are studied explicitly.