Osteocalcin in acute stress response: from the perspective of cardiac diseases. (2nd April 2020)

• Record Type: Journal Article
• Authors: Tian, Aiju; Yang, Chengzhi; Jin, Zening
• Is Part Of: Current medical research and opinion. Volume 36:Number 4(2020)
• Page Start: 545
• Page End: 546
• Publication Date: 2020-04-02
• Subjects: Osteocalcin -- acute stress response (ASR) -- acute myocardial infarction (AMI) -- autonomic nervous system; Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1080/03007995.2020.1723073
• Languages: English
• ISSNs: 0300-7995

Abstract

Abstract: Osteocalcin is an osteoblast-derived peptide mainly found in the bone matrix but also in circulation. A recent investigation suggested that osteocalcin mediated acute stress response (ASR) by inhibiting parasympathetic tone in mice and humans. We propose a hypothesis that osteocalcin is regulated by the skeleton movement and glucocorticoids, and inhibition of the parasympathetic tone by osteocalcin may indicate a therapeutic target in the treatment of acute myocardial infarction (AMI).