Trends and Intensity of Rhinovirus Invasions in Kilifi, Coastal Kenya, Over a 12-Year Period, 2007–2018. (16th November 2021)
- Record Type:
- Journal Article
- Title:
- Trends and Intensity of Rhinovirus Invasions in Kilifi, Coastal Kenya, Over a 12-Year Period, 2007–2018. (16th November 2021)
- Main Title:
- Trends and Intensity of Rhinovirus Invasions in Kilifi, Coastal Kenya, Over a 12-Year Period, 2007–2018
- Authors:
- Mwita Morobe, John
Kamau, Everlyn
Murunga, Nickson
Gatua, Winfred
Luka, Martha M
Lewa, Clement
Cheruiyot, Robinson
Mutunga, Martin
Odundo, Calleb
James Nokes, D
Agoti, Charles N - Abstract:
- Abstract: Background: Rhinoviruses (RVs) are ubiquitous pathogens and the principal etiological agents of common cold. Despite the high frequency of RV infections, data describing their long-term epidemiological patterns in a defined population remain limited. Methods: Here, we analyzed 1070 VP4/VP2 genomic region sequences sampled at Kilifi County Hospital on the Kenya coast. The samples were collected between 2007 and 2018 from hospitalized pediatric patients (<60 months of age) with acute respiratory illness. Results: Of 7231 children enrolled, RV was detected in 1497 (20.7%) and VP4/VP2 sequences were recovered from 1070 samples (71.5%). A total of 144 different RV types were identified (67 Rhinovirus A, 18 Rhinovirus B, and 59 Rhinovirus C ) and at any month, several types co-circulated with alternating predominance. Within types, multiple genetically divergent variants were observed. Ongoing RV infections through time appeared to be a combination of (1) persistent types (observed up to 7 consecutive months), (2) reintroduced genetically distinct variants, and (3) new invasions (average of 8 new types annually). Conclusions: Sustained RV presence in the Kilifi community is mainly due to frequent invasion by new types and variants rather than continuous transmission of locally established types/variants.
- Is Part Of:
- Open forum infectious diseases. Volume 8:Number 12(2021)
- Journal:
- Open forum infectious diseases
- Issue:
- Volume 8:Number 12(2021)
- Issue Display:
- Volume 8, Issue 12 (2021)
- Year:
- 2021
- Volume:
- 8
- Issue:
- 12
- Issue Sort Value:
- 2021-0008-0012-0000
- Page Start:
- Page End:
- Publication Date:
- 2021-11-16
- Subjects:
- coastal Kenya -- invasion -- long-term surveillance -- persistence -- rhinovirus
Communicable diseases -- Periodicals
Medical microbiology -- Periodicals
Infection -- Periodicals
616.9 - Journal URLs:
- http://ofid.oxfordjournals.org/ ↗
http://www.oxfordjournals.org/en/ ↗ - DOI:
- 10.1093/ofid/ofab571 ↗
- Languages:
- English
- ISSNs:
- 2328-8957
- Deposit Type:
- Legaldeposit
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