Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes. (January 2020)

• Record Type: Journal Article
• Authors: Wang, Xuyi; Xie, Cong; Marathe, Chinmay S.; Malbert, Charles-Henri; Horowitz, Michael; Jones, Karen L.; Rayner, Christopher K.; Sun, Zilin; Wu, Tongzhi
• Is Part Of: Diabetes research and clinical practice. Volume 159(2020)
• Publication Date: 2020-01
• Subjects: Ethnicity -- Gastric emptying -- Postprandial glycaemia -- Type 2 diabetes; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2019.107951
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aims: Gastric emptying is a major determinant of postprandial glycaemia in both health and type 2 diabetes (T2DM); the potential impact of ethnicity on gastric emptying is unclear. We compared the rate of gastric emptying of a standardised meal and the associated glycaemic response in Han Chinese and Caucasian patients with T2DM. Methods: 14 Han Chinese and 14 Caucasian T2DM patients, managed by diet and/or metformin monotherapy, underwent concurrent measurements of gastric emptying and blood glucose for 240 min after a 99mTc-calcium phytate-labelled mashed potato meal. Results: Han Chinese patients were slightly younger (P < 0.05), and had a lower BMI (P < 0.05), than Caucasians. There were no differences in either HbA1c or fasting blood glucose between them. Gastric half-emptying time (T50) was shorter (P < 0.05) and the postprandial blood glucose increment greater (P < 0.05) in Han Chinese than Caucasian patients. Both the increment in blood glucose from baseline at 60 min and peak blood glucose were related inversely to T50 (P < 0.05 each). Conclusions: Han Chinese with relatively well-controlled T2DM have more rapid gastric emptying compared to Caucasians, which is associated with a greater postprandial glycaemic excursion. These differences may inform the choice of management, e.g. Han Chinese may particularly benefit from therapies that slow gastric emptying.