Distribution of glycated haemoglobin and its determinants in Indian young adults. (January 2020)

• Record Type: Journal Article
• Authors: Nagarathna, Raghuram; Kaur, Navneet; Anand, Akshay; Sharma, Kanupriya; Dada, Rima; Sridhar, Palukuru; Sharma, Purnendu; Kumar Singh, Amit; Patil, Suchitra; Nagendra, Hongasandra R.
• Is Part Of: Diabetes research and clinical practice. Volume 159(2020)
• Publication Date: 2020-01
• Subjects: Indian Diabetes Risk Score -- Diabetes -- Prediabetes -- Glycated haemoglobin -- Risk factors; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2019.107982
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aim: The aim of the present study is to understand the distribution of A1c in four different age groups in young adults and its relation to other co-variants. Methods: The countrywide data was collected in 2017 in Individuals with high risk analysed by Indian Diabetes Risk Score (IDRS) and self-declared diabetics were identified after screening a sample of 240, 968 individuals from rural (4 villages of about 500 adults each) and urban (4 census enumeration blocks of about 500 adults each) population spanning 65 districts of 29 states/UTs of Indian subcontinent. Blood tests and other detailed assessments were carried out on this selected group. This study presents the analysis of the A1c values of 2862 young adults (<35 years). Results: In the age group of 31–34 years, the proportion of Diabetes (22.36%) and Prediabetes (9.86%) was higher in comparison with younger age groups. Also, Diabetes (7.3%) and Prediabetes (22%) were highest among those who had parental history of DM in both parents as compared to those with Diabetes history in one parent [Diabetes (7.1%) or Prediabetes (19.0%)] and no Diabetes Parental History (Diabetes (7.3%) and Prediabetes (18.3%) cases. BMI was found to play a significant positive correlation with Diabetes and Prediabetes (p < 0.001) with range of A1c. Conclusion: Age, BMI and parental history were found to be correlated with A1c levels in IDRS screened high-risk population. With increasing age, the proportion of Diabetics and Prediabetics also increased with positive correlation of age with A1c levels.