Predictors of hospitalization in patients with rheumatic disease and COVID-19 in Ireland: data from the COVID-19 global rheumatology alliance registry. Issue 2 (13th May 2021)

• Record Type: Journal Article
• Authors: Conway, Richard; Nikiphorou, Elena; Demetriou, Christiana A; Low, Candice; Leamy, Kelly; Ryan, John G; Kavanagh, Ronan; Fraser, Alexander D; Carey, John J; O'Connell, Paul; Flood, Rachael M; Mullan, Ronan H; Kane, David J; Robinson, Philip C; Liew, Jean W; Grainger, Rebecca; McCarthy, Geraldine M
• Is Part Of: Rheumatology advances in practice. Volume 5:Issue 2(2021)
• Publication Date: 2021-05-13
• Subjects: rheumatic disease -- COVID-19 -- biologics -- hospitalization; Rheumatology -- Periodicals; Rheumatology; Rheumatic Diseases; Rheumatology; Periodicals; Electronic journals; Periodical; 616.723005
• DOI: 10.1093/rap/rkab031
• Languages: English
• ISSNs: 2514-1775

Abstract

Abstract: Objectives: Given the limited data regarding the risk of hospitalization in patients with rheumatic disease and coronavirus disease 2019 (COVID-19) in Ireland, we used the COVID-19 Global Rheumatology Alliance (GRA) registry data to study outcomes and their predictors. The primary objective was to explore potential predictors of hospitalization. Methods: We examined data on patients and their disease-related characteristics entered in the COVID-19 GRA provider registry from Ireland (from 24 March 2020 to 31 August 2020). Multivariable logistic regression was used to assess the association of demographic and clinical characteristics with hospitalization. Results: Of 105 patients, 47 (45.6%) were hospitalized and 10 (9.5%) died. Multivariable logistic regression analysis showed that age [odds ratio (OR) = 1.06, 95% CI 1.01, 1.10], number of co-morbidities (OR = 1.93, 95% CI 1.11, 3.35) and glucocorticoid use (OR = 15.01, 95% CI 1.77, 127.16) were significantly associated with hospitalization. A diagnosis of inflammatory arthritis was associated with lower odds of hospitalization (OR = 0.09, 95% CI 0.02, 0.32). Conclusion: Increasing age, co-morbidity burden and glucocorticoid use were associated with hospitalization, whereas a diagnosis of inflammatory arthritis was associated with lower odds of hospitalization.