COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men. (12th June 2021)

• Record Type: Journal Article
• Authors: Demonbreun, Alexis R; Sancilio, Amelia; Velez, Matt E; Ryan, Daniel T; Pesce, Lorenzo; Saber, Rana; Vaught, Lauren A; Reiser, Nina L; Hsieh, Ryan R; D'Aquila, Richard T; Mustanski, Brian; McDade, Thomas W; McNally, Elizabeth M
• Is Part Of: Journal of infectious diseases. Volume 224:Number 5(2021)
• Page Start: 793
• Page End: 797
• Publication Date: 2021-06-12
• Subjects: COVID-19 -- SARS-CoV-2 -- serological testing -- IgG -- ELISA -- dried blood spots -- vaccine -- neutralizing -- receptor binding domain; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab314
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.