Hypoxia‐induced pulmonary vasoconstriction of intra‐acinar arteries is impaired in NADPH oxidase 4 gene‐deficient mice. (1st November 2018)

• Record Type: Journal Article
• Authors: Murtaza, Ghulam; Paddenberg, Renate; Pfeil, Uwe; Goldenberg, Anna; Mermer, Petra; Kummer, Wolfgang
• Is Part Of: Pulmonary circulation. Volume 8:Number 4(2018)
• Page Start: 1
• Page End: 4
• Publication Date: 2018-11-01
• Subjects: NADPH oxidase 4 (NOX4) -- hypoxic pulmonary vasoconstriction -- videomorphometry -- precision‐cut lung slices -- NOX4 knockout mice; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894018808240
• Languages: English
• ISSNs: 2045-8932

Abstract

Abstract : We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra‐acinar, but not pre‐acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilation‐perfusion matching at the acinar level.