Combating amyloid-induced cellular toxicity and stiffness by designer peptidomimetics. Issue 2 (10th January 2022)

• Record Type: Journal Article
• Authors: Konar, Mouli; Ghosh, Debasis; Samanta, Sourav; Govindaraju, Thimmaiah
• Is Part Of: RSC chemical biology. Volume 3:Issue 2(2022)
• Page Start: 220
• Page End: 226
• Publication Date: 2022-01-10
• Subjects: 572
• DOI: 10.1039/d1cb00235j
• Languages: English
• ISSNs: 2633-0679

Abstract

Abstract : Aβ14-23 peptidomimetics incorporated with cyclic dipeptide-based unnatural amino acid at defined positions serve as potential candidates to understand and ameliorate amyloid-induced cellular toxicity and physio-mechanical anomalies. Abstract : Amyloid beta (Aβ) aggregation species-associated cellular stress instigates cytotoxicity and adverse cellular stiffness in neuronal cells. The study and modulation of these adverse effects demand immediate attention to tackle Alzheimer's disease (AD). We present a de novo design, synthesis and evaluation of Aβ14-23 peptidomimetics with cyclic dipeptide (CDP) units at defined positions. Our study identified Akd NMC with CDP units at the middle, N- and C-termini as a potent candidate to understand and ameliorate Aβ aggregation-induced cellular toxicity and adverse stiffness.