Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization. Issue 13 (18th January 2022)

• Record Type: Journal Article
• Authors: Wang, Chenfei; Huang, Xiaobei; Sun, Litao; Li, Qiuxia; Li, Zhili; Yong, Haiyang; Che, Delu; Yan, Cong; Geng, Songmei; Wang, Wenxin; Zhou, Dezhong
• Is Part Of: Chemical communications. Volume 58:Issue 13(2022)
• Page Start: 2136
• Page End: 2139
• Publication Date: 2022-01-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc06480k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Cyclic poly(β-amino ester)s (CPAEs) are synthesized via sequential Michael addition and free radical initiating ring-closure reaction, and show superior gene transfection compared to their linear counterparts. Abstract : Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.